Outcome of pregnancies complicated with vaginal bleeding between 14 and 22 gestational weeks

Methods This is a retrospective cohort study consisting of 669 pregnant women conducted between September, 2010 and December, 2013. The outcomes of the 297 pregnant women with primary vaginal bleeding between 14th and 22nd gestational weeks were assessed. After ruling out patients without follow-up and pregnancies ending in a spontaneous abortion, we examined 232 pregnancies compared with 327 pregnant women without vaginal bleeding. Both of the two groups included 20-35 year-old healthy women with singleton pregnancies. Patients who had known risk factors for spontaneous abortion were excluded from both groups. Patients with morbid obesity (n: 16), uterine septum (n: 10), hypothyroidism (n: 9), thrombophilia (n: 5), asthma (n: 5) and cervical insufficiency (n: 4) were excluded. Power analysis and the sample size calculation were performed before the study. Type-2 statistical error was considered at a level of 0, 20. Statistical analysis was performed using the SPSS software version 18. Normally distributed parametric variables were tested by independent Student’s t-test. The chi square-test was used to analyze nominal variables in the form of frequency tables. Fisher’s exact test was performed instead of Chi-square test due to the expected counts less than 5. A p value less than 0. 05 was considered to show a statistically significant result.